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What Is Leptin Resistance? | Peter Attia, M.D. & Stephan Guyenet

If leptin is a hormone that regulates body fatness, why is it that people with obesity have so much of it, and it’s not suppressing and obese persons body fat mass?

The answer may be leptin resistance.

In the same way that people can develop insulin resistance, where it takes more insulin to do the physiological jobs in the body, people with obesity require more leptin for the hypothalamus to be satisfied.


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